Notch信号通路
癌症研究
肾细胞癌
细胞凋亡
信号转导
肾癌
化学
癌症
细胞生物学
Hes3信号轴
肾癌
癌细胞
后天抵抗
基础（证据）
细胞
抗性（生态学）
肾
癌
血管内皮生长因子受体
细胞信号
医学
程序性细胞死亡
槽口1
受体
调节器
生物
作者
Diaoyi Tan,Yuzhong Ye,Daojia Miao,Chuanyi Zhao,Songming Wu,Jian Shi,Junkai Yang,Kun Fang,Feiyi Lu,Qingyang Lv,Jianlin Gong,Hongmei Yang,Wenjun Xiao,Zhiyong Xiong,Xiaoping Zhang,Hailong Ruan
标识
DOI：10.1016/j.drup.2025.101332
摘要
This study emphasized the importance of UBL3 in VEGFRi resistance in RCC and proposed that UBL3 activated NOTCH signaling through two distinct pathways, thereby suppressing cancer apoptosis and promoting resistance to VEGFRis. These findings provided a solid scientific foundation and paved the way for the development of novel therapeutic strategies for patients with advanced RCC.
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(2025-6-4)
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