The Effect of Aging at Moderate Altitude on Cognition and Symptoms of Depression and Anxiety

Severe hypoxia at very high or extreme altitudes has detrimental effects on brain health, particularly in the aging brain, resulting in cognitive impairment and triggering or aggravating symptoms of depression and anxiety. In contrast, the potential benefits of prolonged exposure to moderate altitudes on brain and mental health, especially in aging populations, remain a topic of debate. The limited number of studies, coupled with the presence of multiple confounding factors, makes it difficult to draw definitive conclusions.