Efficacy of Non‐Ablative Fractional Laser Combined With Tranexamic Acid in Melasma Treatment: A Randomized Split‐Face Trial

The combination of NAFL and topical TXA provides significant short-term clinical benefits in treating melasma, likely by enhancing TXA penetration into target tissues and improving pigmentary clearance. However, its efficacy diminishes over time due to the inevitable recurrence of melasma, necessitating further investigation into long-term maintenance strategies.