化学
钯
催化作用
磷化氢
分子间力
芳基
组合化学
配体(生物化学)
药物化学
有机化学
分子
生物化学
受体
烷基
作者
Debasmita Mondal,Subhendu Pramanik,Chinmay Chowdhury
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-18
卷期号:24 (47): 8698-8702
被引量:4
标识
DOI:10.1021/acs.orglett.2c03625
摘要
Palladium(0)-catalyzed reactions between allenamides 3 or 4 and aryl iodides/bromides 5/6 provide an easy access to δ-carbolines 1 or benzofuro[3,2-b]pyridines 2. The reaction constitutes a fast intermolecular assembly that takes place in one pot, and the choice of the phosphine ligand is critical for success. A plausible reaction mechanism is proposed. The reaction is amenable to the synthesis of bis-heteroannulated products.
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