Platelet Membrane‐Encapsulated Nanocomplexes Based on Profundity Scavenging Ros Strategy for Myocardial Infarction Therapy

Advanced Healthcare MaterialsVolume 13, Issue 8 2303101 Research Article Platelet Membrane-Encapsulated Nanocomplexes Based on Profundity Scavenging ROS Strategy for Myocardial Infarction Therapy Meng Sun, Meng Sun Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 China Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorNan Hu, Nan Hu Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 ChinaSearch for more papers by this authorYangyang Gao, Yangyang Gao The First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorNan Lv, Nan Lv Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorXiaohong Fu, Xiaohong Fu The First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorYafeng Li, Yafeng Li The Nephrology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030012 ChinaSearch for more papers by this authorShaodong Zhai, Corresponding Author Shaodong Zhai [email protected] orcid.org/0000-0001-9726-9329 Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 China E-mail: [email protected]; [email protected]Search for more papers by this authorRuiping Zhang, Corresponding Author Ruiping Zhang [email protected] orcid.org/0000-0001-6922-0747 The Radiology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030001 China E-mail: [email protected]; [email protected]Search for more papers by this author Meng Sun, Meng Sun Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 China Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorNan Hu, Nan Hu Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 ChinaSearch for more papers by this authorYangyang Gao, Yangyang Gao The First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorNan Lv, Nan Lv Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorXiaohong Fu, Xiaohong Fu The First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 ChinaSearch for more papers by this authorYafeng Li, Yafeng Li The Nephrology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030012 ChinaSearch for more papers by this authorShaodong Zhai, Corresponding Author Shaodong Zhai [email protected] orcid.org/0000-0001-9726-9329 Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032 China E-mail: [email protected]; [email protected]Search for more papers by this authorRuiping Zhang, Corresponding Author Ruiping Zhang [email protected] orcid.org/0000-0001-6922-0747 The Radiology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030001 China E-mail: [email protected]; [email protected]Search for more papers by this author First published: 04 January 2024 https://doi.org/10.1002/adhm.202303101Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Ischemia-induced myocardial injury has become a serious threat to human health, and its treatment remains a challenge. The occurrence of ischemic events leads to a burst release of reactive oxygen species (ROS), which triggers extensive oxidative damage and leads to dysfunctional autophagy, making it difficult for cells to maintain homeostasis. Antioxidants and modulation of autophagy have thus become promising strategies for the treatment of ischemic myocardial injury. This study proposes an antioxidant-activated autophagy therapeutic regimen based on combining melanin (Mel), an excellent antioxidant with metformin mimetic ploymetformin via electrostatic interactions, to obtain a nanocomplex (Met-Mel). The nanocomplex is finally encapsulated with platelet membranes (PMN) to construct a biomimetic nanoparticle (PMN@Met-Mel) capable of targeting injured myocardium. The prepared PMN@Met-Mel has good Mel loading capacity and optimal biosafety. It exhibits excellent antioxidant activity and autophagy activation, rapidly restoring mitochondrial function. Moreover, RNA sequencing (RNA-seq) analysis reveals that PMN@Met-Mel operates mechanistically by triggering the activation of the autophagy pathway. Subsequent in vivo experiments showcase promising cardioprotective effects of these nanoparticles. These discoveries present a newly devised nanoplatform with promising potential for the effective treatment of myocardial infarction. Conflict of Interest The authors declare no conflict of interest. Open Research Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article. 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