抑制性突触后电位
兴奋性突触后电位
新皮层
神经科学
视皮层
帕尔瓦布明
锥体细胞
筒状皮质
生物
体感系统
海马体
作者
Petr Znamenskiy,Mean-Hwan Kim,Dylan R. Muir,Maria Florencia Iacaruso,Sonja B. Hofer,Thomas D. Mrsic-Flogel
出处
期刊:Neuron
[Elsevier]
日期:2024-01-01
被引量:3
标识
DOI:10.1016/j.neuron.2023.12.013
摘要
In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic weights of their connections to nearby pyramidal neurons are specifically tuned according to the similarity of the cells’ responses. Individual PV+ cells strongly inhibit those pyramidal cells that provide them with strong excitation and share their visual selectivity. This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-specific excitatory ensembles while supporting competition between them.
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