Nickel-Catalyzed Double Deoxygenative C–N Coupling of Acyloxyamines

A double deoxygenative C–N coupling protocol has been developed by employing acyloxyamines through N–O bond activation. The C–N bond formation under mild reaction conditions, employing NiCl2 as the catalyst and cataCXiumA as a ligand, results in the production of a diverse array of alkylated secondary or tertiary amines, including heterocyclic amines. This method introduces a novel catalytic strategy that emphasizes the versatility of nickel-catalyzed reactions, extending beyond traditional synthetic boundaries.