化学
亚胺
氨基酸
乙醛酸循环
酒
草酸盐
组合化学
立体化学
有机化学
催化作用
酶
生物化学
作者
Gregory R. Alvey,Elena V. Stepanova,Andrey Shatskiy,Josefin Lantz,Rob Willemsen,Aurélio Munoz,Peter Dinér,Markus D. Kärkäs
标识
DOI:10.26434/chemrxiv-2023-dnbpx
摘要
An efficient protocol for the asymmetric synthesis of unnatural amino acids is realized through photoredox-mediated C–O bond activation of oxalate esters derived from aliphatic alcohols as the radical precursors. The developed system uses chiral glyoxylate-derived N-sulfinyl imine as the radical acceptor and allows quick access to a range of functionalized unnatural amino acids through an atom-economical redox-neutral process with CO2 as the only stoichiometric by-product.
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