代谢组学
新陈代谢
有机体
生物转化
代谢途径
内分泌系统
化学
计算生物学
生物化学
生物
生物信息学
酶
激素
遗传学
作者
Jason T. Magnuson,Daniel Schlenk
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2023-01-01
卷期号:: 235-245
标识
DOI:10.1016/b978-0-12-824464-7.00014-3
摘要
Metabolism is a general term of cell biology that implies change of molecular entities, which generally occurs as a result of enzymatic activities generating metabolites from a parent compound. Historically, evaluations have focused on metabolic conversions of xeno- or endo-biotic substances to specific metabolites (classic biotransformation/metabolism). However, recent advances in analytical chemistry and large data set informatic evaluations have allowed scientists not only to evaluate the putative metabolites generated from a parent chemical but also the generation of metabolites created indirectly from endogenous substrates that may be altered by that same chemical (metabolomics). This review will discuss the changes within both of these metabolic processes and impacts they might have on endocrine responses, specifically estrogenic endpoints.
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