Electronic Skin In article number 2202622, by integrating the triboelectric effect with the supercapacitive iontronic effect, Yang Li, Guozhen Shen, and co-workers report an artificial intelligence (AI)-motivated full-skin bionic (FSB) e-skin based on bionic vellus hair and epidermis–dermis–hypodermis double interlocked microcone structures and demonstrate its smart application prospects from tactile perception to advanced intelligent tactile cognition.