癌症研究
转录因子
生物
SOX2
延伸系数
干细胞
雌激素受体
运行x2
细胞生物学
乳腺癌
癌症
遗传学
核糖体
核糖核酸
基因
作者
Long Qian,Mingli Xiang,Linlin Xiao,Jiajia Wang,Xiaoyan Guan,Liu Jian-guo,Chengcheng Liao
出处
期刊:Combinatorial Chemistry & High Throughput Screening
[Bentham Science]
日期:2023-10-05
卷期号:26
标识
DOI:10.2174/0113862073241079230920082056
摘要
As a member of the AF4/FMR2 (AFF) family, AFF4 is a scaffold protein in the superelongation complex (SEC). In this mini-view, we discuss the role of AFF4 as a transcription elongation factor that mediates HIV activation and replication and stem cell osteogenic differentiation. AFF4 also promotes the progression of head and neck squamous cell carcinoma, leukemia, breast cancer, bladder cancer and other malignant tumors. The biological function of AFF4 is largely achieved through SEC assembly, regulates SRY-box transcription factor 2 (SOX2), MYC, estrogen receptor alpha (ESR1), inhibitor of differentiation 1 (ID1), c-Jun and noncanonical nuclear factor-κB (NF-κB) transcription and combines with fusion in sarcoma (FUS), unique regulatory cyclins (CycT1), or mixed lineage leukemia (MLL). We explore the prospects of using AFF4 as a therapeutic in Acquired immunodeficiency syndrome (AIDS) and malignant tumors and its potential as a stemness regulator.
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