化学
催化作用
机制(生物学)
芳基
组合化学
有机化学
立体化学
哲学
烷基
认识论
作者
Michael A. W. Eaton,Webster L. Santos,Zhuochen Wang,Bo Li,Walid Lamine,Karinne Miqueu,Shih‐Yuan Liu
摘要
A method for the synthesis of allenes by the addition of ketones to 1,3-enynes by cooperative Pd(0)Senphos/B(C6F5)3/NR3 catalysis is described. A wide range of aryl- and aliphatic ketones undergo addition to various 1,3-enynes in high yields at room temperature. Mechanistic investigations revealed a rate-determining outer-sphere proton transfer mechanism, which was corroborated by DFT calculations.
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