Transient expression of Reg3Β by smooth muscle cells affects atherosclerosis in mice

Background and Aims: Inflammatory reactions within arterial walls are major hallmarks of atherosclerosis and contribute to the initiation and progression of the disease. Recent studies by our group uncovered regenerating islet-derived proteins (Reg) as central hubs for orchestrating immune-inflammatory reactions during cardiac remodeling. The present work aimed to study a potential contribution of the paralogue Reg3β for progression of atherosclerosis.