TLR4型
Toll样受体
免疫系统
受体
疾病
发病机制
信号转导
伤亡人数
TLR7型
免疫学
医学
神经科学
生物
生物信息学
先天免疫系统
细胞生物学
内科学
作者
Wei Ji,Yan Zhang,H. Li,Fuquan Wang,Shanglong Yao
标识
DOI:10.1016/j.biopha.2023.115338
摘要
The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.
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