Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy

An oxygen self-supplying nanoplatform utilizing perfluorocarbon-functionalized porphyrinic MOFs was developed to alleviate tumor hypoxia. This strategy combines external oxygen-delivery with in situ oxygen generation via cascade reactions, resulting in enhanced synergistic effects for both cancer starvation therapy and robust photodynamic therapy.