光热治疗
金属有机骨架
药物输送
纳米技术
药品
水溶液中的金属离子
癌症治疗
聚合物
金属
化学
材料科学
癌症
药理学
医学
有机化学
内科学
吸附
冶金
复合材料
作者
Mojtaba Moharramnejad,Rahime Eshaghi Malekshah,Ali Ehsani,Sajjad Gharanli,Mehrnaz Shahi,Saeed Alvani Alvan,Zahra Salariyeh,Maryam Nasr Azadani,Jebiti Haribabu,Zahra Salmanivand Basmenj,Ali Khaleghian,Hossein Saremi,Zahra Hassani,Elham Momeni
标识
DOI:10.1016/j.cis.2023.102908
摘要
Metal-organic frameworks (MOFs), also called porous coordination polymers, represent a class of crystalline porous materials made up of organic ligands and metal ions/metal clusters. Herein, an overview of the preparation of different metal-organic frameworks and the recent advances in MOF-based stimuli-responsive drug delivery systems (DDSs) with the drug release mechanisms including pH-, temperature-, ion-, magnetic-, pressure-, adenosine-triphosphate (ATP)-, H2S-, redox-, responsive, and photoresponsive MOF were rarely introduced. The combination therapy containing of two or more treatments can be enhanced treatment effectiveness through overcoming limitations of monotherapy. Photothermal therapy (PTT) combined with chemotherapy (CT), chemotherapy in combination with PTT or other combinations were explained to overcome drug resistance and side effects in normal cells as well as enhancing the therapeutic response. Integrated platforms containing of photothermal/drug-delivering functions with magnetic resonance imaging (MRI) properties exhibited great advantages in cancer therapy.
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