流出
抗生素
抗菌活性
微生物群
药品
大肠杆菌
抗菌剂
计算生物学
微生物学
行动方式
基因
生物
药理学
细菌
毒理
遗传学
作者
Mariana Noto Guillen,Carmen G Li,Brittany Rosener,Amir Mitchell
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2024-03-14
卷期号:384 (6691): 93-100
被引量:39
标识
DOI:10.1126/science.adk7368
摘要
Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic screens with thousands of barcoded
科研通智能强力驱动
Strongly Powered by AbleSci AI