Angiopep-2 modified naringin nanoparticles for Alzheimer’s disease therapy overcoming BBB

, ANG-NG-NPs extended NG's circulation time and increased brain uptake. Notably, ANG-NG-NPs restored learning and memory in APP/PS1 mice, improved hippocampal cell health, and reduced hyperphosphorylated tau protein (p-Tau) expression. These findings suggest ANG-NG-NPs as a promising brain-targeting system for treating central nervous system disorders.