CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway

These findings suggest that CD147 is closely involved in keloid progression. Inhibition of CD147 downregulates TGF-β1-induced fibronectin expression in KFs by targeting Smad2 signaling pathway. Thus, CD147 may serve as a promising therapeutic target for keloid treatment.