Local Delivery of Various Hormonal Drugs Along With Bone Grafts to Improve Osteogenesis: A Systematic Review

This review aimed to investigate the effect of local delivery of various hormonal drugs and bone grafts to improve osteogenesis. The study included a systematic literature search covering the time period from 1970 to December 2023 using PubMed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A structured search was performed to identify in vivo and in vitro studies. In total, 22 studies were covered after screening the articles based on title and abstract. All of the studies included were animal in vivo studies or in vitro studies and used parathyroid hormone (PTH), growth hormone (GH), and calcitonin. In addition, 87.5% of the studies that used GH reported better outcomes than the control groups; and 66.7% of the studies that used PTH achieved superior outcomes compared to the control group. Moreover, 60% of the studies that used calcitonin achieved superior outcomes compared to the control group. The findings indicated that locally administered hormonal drugs may positively affect osteogenesis in vivo and in vitro. This is especially true for PTH in the healing of surgical bone defects and peri-implant response and for GH in peri-implant bone response. Locally administered hormonal drugs may stimulate bone healing in surgical bone defects and enhance peri-implant bone response.