Recent Advances in Electrochemical Benzylic C(sp3)−H Functionalization

Direct benzylic C(sp3)–H functionalization has emerged as a topic in organic synthesis due to its critic role in constructing complex and valuable molecules. Among the various methodologies employed, electroorganic synthesis has garnered considerable attention in diversifying benzylic C(sp3)–H functionalization. In recent years, substantial progress has been made in electrochemical benzylic C(sp3)–H functionalization. However, a comprehensive review summarizing recent advancements in this area is still lacking. This review provides an overview of the latest developments (2021–2025) in electrochemical benzylic C(sp3)–H functionalization, with a particular emphasis on mechanistic insights and practical applications in the synthesis of biologically active molecules. Additionally, current challenges and future perspectives in this field are discussed.