Deciphering immune dynamics in atherosclerosis: Inflammatory mediators as biomarkers and therapeutic target

Abstract Background Atherosclerosis, one of the main causes of cardiovascular disease, is driven by complex interactions between lipid metabolism and immune mechanisms in the vascular system. Regulatory molecules, particularly protein fragments derived from cytokines, chemokines and other immune‐related proteins, play a central role in modulating inflammation and immune responses in atherosclerotic plaques. Results Recent advances in peptidomics have revealed the dual role of immune system‐derived peptides as indicators and effectors of atherosclerotic cardiovascular disease (ASCVD). Certain subsets of immune cells, such as pro‐inflammatory monocytes and regulatory T cells, contribute to this peptide‐mediated regulation. New findings suggest that these peptides may serve as diagnostic biomarkers and therapeutic targets in atherosclerosis. Conclusion This review highlights the translational relevance of immune‐mediated peptides in ASCVD and emphasizes their diagnostic and therapeutic potential. By integrating peptidomics with immunology research, a new framework for understanding and targeting inflammation in atherosclerosis is proposed, opening new avenues for precision medicine in cardiovascular care.