壳聚糖
自愈水凝胶
肿胀 的
复合数
化学工程
化学
控制释放
材料科学
多孔性
高分子化学
纳米技术
复合材料
有机化学
工程类
作者
Youssra Ben Azaza,Arie van der lee,Suming Li,Monçef Nasri,Rim Nasri
标识
DOI:10.1016/j.scp.2022.100905
摘要
Marine biopolymers obtained from fishery by-products, such as chitosan and collagen, are sustainable alternatives to developing eco-friendly hydrogels. This work focused on the development of composite hydrogels based on blue crab chitosan (Cs) and bluefin tuna collagenous protein (BTCP), at different concentrations (10%, 20%, and 50%; w/w Cs), by using a freezing/thawing approach. Cs-BTCP composite hydrogels were characterized in terms of structural, morphological, thermal, mechanical, rheological, and antioxidant properties. A highly interconnected porous structure is shown for all the freeze-dried composite chitosan hydrogels by SEM imaging. Additionally, by increasing the concentration of BTCP, the porosity, and swelling degree of the composite hydrogels were improved. Data also revealed that BTCP addition enhanced the elasticity and mechanical resistance of composite hydrogels, especially HG prepared with 50% of BTCP, which explain its high swelling ability which reaches 2160% compared to 1396% for HG-C, at pH 5.5. HG-50 was selected for the in vitro release study of phycocyanin as a bioactive molecule and the results revealed that the release depends on the medium pH. Kinetic studies show that phycocyanin release is mainly governed by drug diffusion. Therefore, pH-sensitive Cs-BTPC composite hydrogels could provide an appropriate and supportive microenvironment for the loading and administration of drugs.
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