Aminotetrazole Synthesis from Secondary Amides by C–C Bond Nitrogenation

Abstract The development of novel methods for the preparation of aminotetrazoles is of long-standing interest to chemists due to the great importance of these compounds in chemistry and biology. Here, we report an efficient method for the preparation of aminotetrazoles from secondary amides by selective C–C bond cleavage. Compared with the conventional laborious and cumbersome approaches to aminotetrazoles, this chemistry provides a highly efficient nitrogenation strategy, with the installation of four nitrogen atoms into a secondary amide in one step.