生物膜
光热治疗
材料科学
金黄色葡萄球菌
体内
抗生素
微生物学
耐甲氧西林金黄色葡萄球菌
纳米技术
细菌
生物
遗传学
生物技术
作者
Xin‐Jin Su,Zhuocheng Lyu,Yuezhou Wu,Yue-Huan Gu,Shicheng Huo,Chun Zhou
标识
DOI:10.1016/j.matdes.2022.111552
摘要
The infection of implants following orthopedic surgery is a “catastrophic” surgical complication, particularly when biofilms form, protecting bacteria from antibiotics as well as the patient’s immune system. To address the current difficulties in treating biofilm infections, we fabricate a functional strontium doped bioactive glass nanoparticles (Sr-BGNs)-instructed orthopedic implant composed of PEEK, Sr-BGNs and polydopamine (PDA). In addition to destroying the permeability and integrity of MRSA biofilm, PDA also endowed PEEK substrate with effective antibacterial ability when exposing to near-infrared (NIR) irradiation. The NIR mediated photothermal disruption of biofilms contributed to the advanced antibacterial therapy, which has been validated by the efficient eradication of methicillin-resistant Staphylococcus aureus strains (MRSA) biofilm in vitro and in vivo. Notably, the engineered implants exhibit satisfactory cytocompatibility. In addition, Sr ions released from Sr-BGNs inhibited the expression of inflammatory genes, thereby providing a superior environment for tissue repair after infection clearance. The synergistic effect of photothermal effect and immunomodulatory property might have promising applications for preventing perioperative infection and tissue repair after infection.
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