酰基转移酶
化学生物学
化学生态学
生物
基因家族
部分
计算生物学
基因
小分子
生物化学
化学
生物合成
生态学
立体化学
基因表达
作者
Gaurav D. Moghe,Lars Kruse,Maike Petersen,Federico Scossa,Alisdair R. Fernie,Emmanuel Gaquerel,John C. D’Auria
标识
DOI:10.1146/annurev-arplant-062922-050122
摘要
Plants’ ability to chemically modify core structures of specialized metabolites is the main reason why the plant kingdom contains such a wide and rich array of diverse compounds. One of the most important types of chemical modifications of small molecules is the addition of an acyl moiety to produce esters and amides. Large-scale phylogenomics analyses have shown that the enzymes that perform acyl transfer reactions on the myriad small molecules synthesized by plants belong to only a few gene families. This review is focused on describing the biochemistry, evolutionary origins, and chemical ecology implications of one of these families—the BAHD acyltransferases. The growth of advanced metabolomic studies coupled with next-generation sequencing of diverse plant species has confirmed that the BAHD family plays critical roles in modifying nearly all known classes of specialized metabolites. The current and future outlook for research on BAHDs includes expanding their roles in synthetic biology and metabolic engineering.
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