子痫
医学
螺旋动脉
滋养层
病理生理学
病因学
病例对照研究
内科学
前瞻性队列研究
胃肠病学
怀孕
产科
胎儿
生物
胎盘
遗传学
作者
İrem Eda Gökdemir,Özlem Özdeğirmenci,Burak Elmas,Esma Sarıkaya,Aytekin Tokmak,Fatmanur Hacıevliyagil Kazancı,Sümeyye Gök,Salım Erkaya,Kadir Demircan
标识
DOI:10.3109/14767058.2015.1087497
摘要
Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p < 0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p > 0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27 ng/ml while the cut-off value for IL-33 was 0.23 pg/ml with 82.93% sensitivity and 53.66% specificity.Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.
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