운동이 흰쥐의 대장에서 종양억제 유전자 발현

The purpose of this study was to investigate a member of tumor suppressing genes in intestine according to different intensity of treadmill exercise with Sprague Dawley Rats. Assigned groups of the rats were as followings: control group (no exercise), low-intensity exercise group (8 m/min of treadmill) and high-intensity exercise group (28 m/min of treadmill). The exercise groups ran for 30 min/day in a frequency of 4 days/week for 4 weeks on treadmill. As results, there were 7 genes were constructed. Only Rhos (rashemoglog gene family memberh) showed decreased in the low-intensity exercise group and increased in the high-intensity exercise group. It was decreased 10 times in the low intensity exercise group and increased 3.1 times in the high intensity exercise group. Additionally there were 5 genes which were decreased in both low intensity and high intensity exercise groups. Namely, Vldlr (very low density lipoprotein receptor) was decreased 1.2 times and 11.3 times in the low intensity exercise group and high intensity exercise groups respectively. Tiam 2 (T-cell lymphoma invasion and metastasis 2) was decreased 8.8 times in the low intensity exercise group and 19.1 times at high intensity exercise group. Lcn 2 (lipocalin 2) was increased in both low-intensity exercise and high intensity exercise groups. It showed 17.09 times and 99.67 times increase in the low-intensity exercise group and high intensity exercise group. Dmbt 1 (deleted in malignant brain tumors) showed 9.1 times increase in the low-intensity exercise group and 10.5 times in the high intensity exercise group.