Solid state synthesis and characterization of calcium phosphate for biomedical application

In recent years calcium phosphates (CaPs) consisting of tricalcium phosphate (TCP)and hydroxyapatite, have attracted significant interest in different applications like scaffolds (orthopaedic, oral and maxillofacial surgery), dental cement (adhesives, void fillers), bone cement (coating of implants, bone grafting, void fillers) and delivery systems (BMPs, proteins, drugs). Objective of this work is to synthesis a calcium phosphate by solid state reaction at high temperature using the mixture of calcium carbonate (CaCO3) and di- calcium phosphate anhydrous (CaHPO4), and evaluate the biphasic calcium phosphate containing tricalcium phosphate (Ca3(PO4)2) and hydroxyapatite (HA) for cementing application. The resulting mixtures were characterized and determined by using X-ray diffraction analyses confirmed the phase purity, particle size, phase difference, and crystallinity. Cross-links and functional groups between mixture of solids where determined using Fourier transform infrared spectroscopy (FTIR). It can be concluded that the synthesised hydroxyapatite had a significant clinical advantage, and might have potential to be applied in orthopaedic, reconstructive and maxillofacial surgery, dental void fillers especially for minimally invasive techniques.