细胞外小泡
免疫原性
胞外囊泡
微泡
细胞生物学
细胞内
细胞
小RNA
化学
计算生物学
纳米技术
生物
免疫系统
免疫学
材料科学
生物化学
基因
作者
Dhruvitkumar S. Sutaria,Mohamed Badawi,Mitch A. Phelps,Thomas D. Schmittgen
标识
DOI:10.1007/s11095-017-2123-5
摘要
Extracellular vesicles (EVs) represent a class of cell secreted organelles which naturally contain biomolecular cargo such as miRNA, mRNA and proteins. EVs mediate intercellular communication, enabling the transfer of functional nucleic acids from the cell of origin to the recipient cells. In addition, EVs make an attractive delivery vehicle for therapeutics owing to their increased stability in circulation, biocompatibility, low immunogenicity and toxicity profiles. EVs can also be engineered to display targeting moieties on their surfaces which enables targeting to desired tissues, organs or cells. While much has been learned on the role of EVs as cell communicators, the field of therapeutic EV application is currently under development. Critical to the future success of EV delivery system is the description of methods by which therapeutics can be successfully and efficiently loaded within the EVs. Two methods of loading of EVs with therapeutic cargo exist, endogenous and exogenous loading. We have therefore focused this review on describing the various published approaches for loading EVs with therapeutics.
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