Note Synthesis and antibacterial activity of benzamides and sulfonamide derived from 2- amino-5-bromo/nitropyridine against bacterial strains isolated from clinical patients

A series of 5-(bromo/nitropyridin-2-yl)benzamide derivatives, viz. N-(5-bromopyridin-2-yl)benzamide 4a, 4-methyl-N-(5bromopyridin-2-yl)benzamide 4b, 4-chloro-N-(5-bromopyridin-2yl)benzamide 4c, 4-nitro-N-(5-bromopyridin-2-yl)benzamide 4d , N-(5-nitropyridin-2-yl)benzamide 7a, 4-methyl-N-(5-nitropyridin2-yl)benzamide 7b, 4-chloro-N-(5-nitropyridin-2-yl)benzamide 7c, 4-nitro-N-(5-nitropyridin-2-yl)benzamide 7c and a sulfonamide derivative, N-benzoyl-N-(5-bromopyridin-2-yl)trifluoromethane sulfonamide 5 have been synthesized as novel antibacterial agents. All compounds have shown promising activity (MIC 0.22–1.49 μM) against Gram-positive and Gram-negative bacterial strains using microdilution broth susceptibility test method. The sulfonamide 5 showed much better results than other compounds and its MIC values predicted it to be a lead compound as an antibacterial agent.