足三里
PPAD
迷走神经
医学
电针
药理学
针灸科
刺激
背运动核
迷走神经电刺激
迷走神经切断术
内科学
内分泌学
兴奋剂
麻醉
受体
病理
替代医学
作者
Hee-Don Lim,Min-Hee Kim,Chan Yong Lee,Uk Namgung
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2016-03-18
卷期号:11 (3): e0151882-e0151882
被引量:82
标识
DOI:10.1371/journal.pone.0151882
摘要
Although acupuncture therapy is widely used in traditional Asian medicine for the treatment of diverse internal organ disorders, its underlying biological mechanisms are largely unknown. Here, we investigated the functional involvement of acupuncture stimulation (AS) in the regulation of inflammatory responses. TNF-α production in mouse serum, which was induced by lipopolysaccharide (LPS) administration, was decreased by manual acupuncture (MAC) at the zusanli acupoint (stomach36, ST36). In the spleen, TNF-α mRNA and protein levels were also downregulated by MAC and were recovered by using a splenic neurectomy and a vagotomy. c-Fos, which was induced in the nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus nerve (DMV) by LPS and electroacupuncture (EAC), was further increased by focal administration of the AMPA receptor blocker CNQX and the purinergic receptor antagonist PPADS. TNF-α levels in the spleen were decreased by CNQX and PPADS treatments, implying the involvement of inhibitory neuronal activity in the DVC. In unanesthetized animals, both MAC and EAC generated c-Fos induction in the DVC neurons. However, MAC, but not EAC, was effective in decreasing splenic TNF-α production. These results suggest that the therapeutic effects of acupuncture may be mediated through vagal modulation of inflammatory responses in internal organs.
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