The contents of Lycium barbarum L. polysaccharides(LBP) in the normal and defective fruits of Lycium barbarum L. from different producing areas were analyzed. The results showed that the LBP contents in the normal fruits of different areas were 2.54%~3.52%, the LBP contents in the defective fruits were 2.10%~6.03%. Among them, the LBP content in the defective fruit of Lycium barbarum L. from Touying in Guyuan was the highest, namely, 6.03%, 1.63 times of that of the normal fruit, followed by the LBP content of the defective fruit from Baotou in Inner Mongolia, namely, 5.77%, 1.76 times of that of the normal fruit. In addition to Qinghai and Xinjiang, LBP contents of the defective fruits of the other areas were all higher than that of the normal fruit. In conclusion, the LBP extracted as an immune synergist from the defective fruits of Lycium barbarum L. has a broad application prospect in animal production.