医学
视神经脊髓炎
基于体素的形态计量学
体素
白质
多发性硬化
大脑大小
核医学
灰质
磁共振成像
体积热力学
水通道蛋白4
作者
Yunyun Duan,Yaou Liu,Peipeng Liang,Jing Huang,Zhuoqiong Ren,Jing Ye,Huiqing Dong,Hai Chen,Li Kuncheng
出处
期刊:Chinese journal of radiology
日期:2012-11-10
卷期号:46 (11): 983-987
标识
DOI:10.3760/cma.j.issn.1005-1201.2012.11.005
摘要
Objective To detect changes of regional grey matter and white matter volume in patients of neuromyelitis optica (NMO) by voxel-based morphometry (VBM),and investigate its relationship with clinical variables.Methods Conventional magnetic resonance imaging (MRI) and structural threedimensional MRI were obtained from 20 NMO and 20 sex-and age-matched healthy volunteers.The comparison of grey matter and white matter volume between the two groups was analyzed by VBM tools of statistical parametric mapping (SPM) 5.Pearson correlational analysis was used to assess correlations between regional volume decrease and disease duration and expanded disability status scale (EDSS) scores in NMO patients.Results Compared with normal controls,NMO patients had grey matter atrophy in several cortical regions,such as right inferior frontal gyrus (cluster size 514),left superior temporal gyrus (282),right middle temporal gyvus (229) and right insula (211) (t =3.58-5.11,AlphaSim corrected,P <0.05).White matter atrophy was found in several subcortical regions in NMO patients,such as right precentral and postcentral gyrus (cluster size 457,110),left middle frontal gyrus (285),and right inferior parietal lobule (231) (t =2.90-4.25,AlphaSim corrected,P < 0.05).Grey matter and white matter volume loss were not significantly correlated with clinical duration or EDSS score in NMO.Conclusion By means of VBM,regional atrophy of grey matter and white matter is found in NMO patients,which may provide evidence for brain structural abnormality in NMO.
Key words:
Neuromyelitis optica; Magnetic resonance imaging; Comparative study
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