Recent Advancement in Human Organic Cation Transporter 2 and its Genetic Variants

The human organic cation transporter 2(OCT2,SLC22A2)is one of organic cations transporters family.OCT2 is a multispecific transporter of organic cations,including a lot of clinically used drugs and endogenous compounds.OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is regarded as a major transporter in the active secretion of organic cations in the kidney.Uptake of organic cations by OCT2 is driven by the inside-negative membrane potential and is pH-sensitive.Regulation of OCT2 at the transcriptional level by steroid hormones,While at the protein level by various protein kinases.Kinds of structurally diverse compounds have been shown to interact with OCT2,including endogenous compounds,drugs,and dietary supplements.Several human genetic variants in the coding region of OCT2 have been identified and functionall characterized,including both polymorphic,frequency and rare variants.