STUDY ON THE CHANGES OF MONOAMINE NEUROTRANSMITTER CONTENTS IN HYPOTHALAMUS OF AGING RATS

Objective:To observe the changes of monoamine neurotransmitter contents in hypothalamus of aging rats.Methods: The sub-acutely aging rats were made by injecting D-gal into the rats' abdominal cavity continually and the monoamine transmitter contents in hypothalamus were detected with HPLC-ECD. Results:The NE, DA, 5-HT contents in hypothalamus of aging rats decreased significantly compared with normal rats (P0.01). Conclusions: The monoamine neurotransmitter contents in brain of D-gal aging rats decreased significantly, this maybe one of the mechanisms that D-gal inducing aging.