Clinical analysis of newborns with respiratory syncytial virus and lower respiratory tract infection

OBJECTIVE To study the clinical characteristics of newborns with respiratory syncytial virus and lower respiratory tract infection.METHODS A total of 260 newborns with respiratory syncytial virus and lower respiratory tract infection in our hospital from May 2008 to Apr 2011 were selected as research object.The treatment effect of oxygen therapy,atomization,antiviral drugs and antibiotics,and the hospitalization time and serum IL-4,IL-6,IL-12,CRP,IgE and peripheral blood T lymphocyte subsets of patients before and after the treatment were analyzed and compared.RESULTS Totally 239 cases of 260 patients were cured,20 cases were improvements,1case was ineffective,hospitalization time were(12.8±2.8)d,levels of serum IL-4,IL-6,IL-12,CRP and CD8+ after the treatment were(7.55±2.69)ng/L,(16.69±7.14)ng/L,(56.48±13.39)ng/L,6.88±2.39)mg/L and(26.52±5.69)%,they were higher than(41.58±8.42)ng/L,(90.25±12.42)ng/L,(20.57±5.41)ng/L,(15.96±6.82)mg/L,(36.59±5.33)% before the treatment,IgE,CD3+,CD4+,CD4+/CD8+ after the treatment were(808.34±205.30)μg/L,(63.12±5.20)%,(45.58±5.20)%,(1.68±0.43)%,they were lower than that before the treatment,there were significant or very significant differences.CONCLUSION The effects of the treatment for newborns with respiratory syncytial virus and lower respiratory tract infection are better,and it can significantly improve the inflammatory factors and immune state.