Synthesis of 1,4-Diazabicyclo [2,2,2] Octane with Alkaline Earth Phosphate Catalysts

Here we report on the discovery and development of a new catalyst based on strontium hydrogen phosphate for efficient production of DABCO, 1,4-diazabicyclo [2,2,2] octane. It was brought from initial lab scale discovery to commercial use in less than 1 year. It provides significant value for production of DABCO via much higher selectivity and nearly double the productivity of the silica–alumina material used as the previous commercial catalyst. The value is not only in higher observed productivity but also in large savings in feedstock costs derived from the improved reaction selectivity and also a much longer effective useful lifetime than the previous silica–alumina.