MOG-IgG-Positive Spinal Myelitis a Likely Variant of Neuromyelitis Optica: Overcoming Difficulties in Clinic, Diagnostic, and Therapy

Introduction: Neuromyelitis optica (NMO) is an inflammation demyelinating autoimmune disease; it is now known to be its own entity. NMO now refers to a syndrome characterized by severe bilateral optic neuritis associated with a transverse extensive myelitis, which spans more than three consecutive vertebral segments. Furthermore, AQP4 antibody is a specific autoantibody and targets aquaporin-4 water channel. It is detected in 80% of adult NMO patients. Our report presents a patient with relapsing severe longitudinal myelitis, AQP-4-seronegative, which we would tend to class etiologically as an NMO variant.