蛋白质聚集
蛋白质折叠
化学
蛋白质结构
生物物理学
生物
生物化学
作者
Shweta Devi,Minal Chaturvedi,Siraj Fatima,Smriti Priya
出处
期刊:Toxicology
[Elsevier BV]
日期:2021-11-21
卷期号:465: 153049-153049
被引量:29
标识
DOI:10.1016/j.tox.2021.153049
摘要
The adverse physiological conditions have been long known to impact protein synthesis, folding and functionality. Major physiological factors such as the effect of pH, temperature, salt and pressure are extensively studied for their impact on protein structure and homeostasis. However, in the current scenario, the environmental risk factors (pollutants) have gained impetus in research because of their increasing concentrations in the environment and strong epidemiologic link with protein aggregation disorders. Here, we review the physiological and environmental risk factors for their impact on protein conformational changes, misfolding, aggregation, and associated pathological conditions, especially environmental risk factors associated pathologies.
科研通智能强力驱动
Strongly Powered by AbleSci AI