Relationship between peroxisome proliferators-activated receptor and atherosclerosis

The pathological essence of atherosclerosis is the chronic inflammation of the vascular intima to sustained injury. Peroxisome proliferators-activated receptorα (PPAR-α)is a nuclear receptor activated by natural ligands such as fatty acids as well as by synthetic ligands such as fibrates. PPARα regulates the lipids metabolism,glucose hemeostasis and insulin sensitivity.Furthermore,the recent research indicated that it can also attenuate the initiation and progression of Atherosclerosis, stabilize the atheroplague,even reverse the atherosclerotic lesion,prevent the acute cardiovascular accidents. this article give us a brief review about the relationship between PPAR-α and atherosclerosis.