Acute Hemodynamic Effects and Tolerability of Phosphodiesterase-1 Inhibition With ITI-214 in Human Systolic Heart Failure
内科学
心脏病学
血流动力学
心率
收缩性
作者
Nisha A. Gilotra,Adam D. DeVore,Thomas J. Povsic,Allison G. Hays,Virginia S. Hahn,Tolu A. Agunbiade,Allison DeLong,Andrew Satlin,Richard Chen,Robert L. Davis,David A. Kass
Background: PDE1 (phosphodiesterase type 1) hydrolyzes cyclic adenosine and guanosine monophosphate. ITI-214 is a highly selective PDE1 inhibitor that induces arterial vasodilation and positive ino...