信号灯
细胞生物学
肌球蛋白
塞马3A
淋巴系统
生物
免疫系统
受体
丛蛋白
淋巴管内皮
免疫学
生物化学
作者
Hyota Takamatsu,Noriko Takegahara,Yukinobu Nakagawa,Michio Tomura,Masahiko Taniguchi,Roland H. Friedel,Helen Rayburn,Marc Tessier‐Lavigne,Yutaka Yoshida,Tatsusada Okuno,Masayuki Mizui,Sujin Kang,Satoshi Nojima,Tohru Tsujimura,Yuji Nakatsuji,Ichiro Katayama,Toshihiko Toyofuku,Hitoshi Kikutani,Atsushi Kumanogoh
摘要
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
科研通智能强力驱动
Strongly Powered by AbleSci AI