粒体自噬
线粒体
线粒体生物发生
细胞生物学
细胞适应
生物
生物发生
线粒体融合
线粒体DNA
功能(生物学)
平衡
细胞器
细胞器生物发生
自噬
遗传学
基因
细胞凋亡
作者
Konstantinos Palikaras,Nektarios Tavernarakis
标识
DOI:10.1016/j.exger.2014.01.021
摘要
Mitochondria are highly dynamic organelles and their proper function is crucial for the maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two pathways that regulate mitochondrial content and metabolism preserving homeostasis. The tight regulation between these opposing processes is essential for cellular adaptation in response to cellular metabolic state, stress and other intracellular or environmental signals. Interestingly, imbalance between mitochondrial proliferation and degradation process results in progressive development of numerous pathologic conditions. Here we review recent studies that highlight the intricate interplay between mitochondrial biogenesis and mitophagy, mainly focusing on the molecular mechanisms that govern the coordination of these processes and their involvement in age-related pathologies and ageing.
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