Switchable Diastereoselectivity in Enantioselective [4+2] Cycloadditions with Simple Olefins by Asymmetric Binary Acid Catalysis

The exchange of the metal ion from InIII to ScIII in a binary acid catalyst leads to a switch in the diastereoselectivity of [4+2] cycloadditions. Simple olefins and β,γ-unsaturated α-ketoester were thus transformed to the corresponding exo or endo products, respectively, with excellent diastereoselectivity (up to 99:1 d.r.) and enantioselectivity (up to 99 % ee). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.