E-cadherinis not frequently mutated in hereditary gastric cancer

sites.Even through the use of large YAC constructs, we know that not all the components necessary for regulation of transcription have been identified, nor will they be found in proximity to the coding region for the gene of interest.c-MYC is no exception in that deregulation can occur in conjunction with chromosomal translocations located as far downstream as the PVT locus (260 kb distant to c-MYC).Thus, we have attempted to identify alleles of c-MYC and to compare rates of transcription in a search for controlling regulatory elements in c-MYC.Through the identification of CAA-33, S11N, and S288K alleles, we can begin the process of systematic classification of c-MYC expression and predisposition to disease.