The N‐Substitution of Aliphatic Primary Amines via 1‐[(Alkylamino)methyl]benzotriazoles: Preparation of Secondary Amines

Abstract A new method has been developed for the selective conversion of primary aliphatic amines into unsymmetrical secondary amines by Grignard reaction of 1‐[(alkylamino)methyl]‐benzotriazoles 1. This method employs simple procedure and mild conditions, and is specific in that only monoalkylation of the primary amines results.