Microwaves represent an alternative way of power input into distillation process. Through dielectric heating, reaction mixtures are homogenously heated without contact to a wall. Reaction times are significantly reduced compared to conventionally (thermally) heated systems while maintaining selectivity. In this paper, microwave field select heating on two-phase system has been investigated numerically and experimentally. Temperature increasing, heat transfer and evaporation during heating process were analyzed. The possibility of microwave used for distillation was examined and proposed.