促甲状腺素释放激素
下丘脑
内科学
内分泌学
激素
分泌物
下丘脑-垂体-甲状腺轴
激素原
神经元
核心
生物
化学
神经科学
医学
甲状腺激素
标识
DOI:10.1016/j.yfrne.2010.01.001
摘要
The hypothalamic-pituitary-thyroid (HPT) axis plays a critical role in mediating changes in metabolism and thermogenesis. Thus, the central regulation of the thyroid axis by Thyrotropin Releasing Hormone (TRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) is of key importance for the normal function of the axis under different physiological conditions including cold stress and changes in nutritional status. Before the TRH peptide becomes biologically active, a series of tightly regulated processes occur including the proper folding of the prohormone for targeting to the secretory pathway, its post-translational processing, and targeting of the processed peptides to the secretory granules near the plasma membrane of the cell ready for secretion. Multiple inputs coming from the periphery or from neurons present in different areas of the brain including the hypothalamus are responsible for the activation or inhibition of the TRH neuron and in turn affect the output of TRH and the set point of the axis.
科研通智能强力驱动
Strongly Powered by AbleSci AI