PCSK9
低密度脂蛋白受体
可欣
前蛋白转化酶
医学
肽疫苗
免疫学
抗体
胆固醇
单克隆抗体
免疫系统
家族性高胆固醇血症
药理学
脂蛋白
内科学
表位
作者
Gergana Galabova,Sylvia Brunner,Gabriele Winsauer,Claudia Juno,Bettina Wanko,Andreas Mairhofer,Petra Lührs,Achim Schneeberger,Arne von Bonin,Frank Mattner,Walter Schmidt,Guenther Staffler
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2014-12-04
卷期号:9 (12): e114469-e114469
被引量:135
标识
DOI:10.1371/journal.pone.0114469
摘要
Peptide-based anti-PCSK9 vaccines induce the generation of antibodies that are persistent, high-affine, and functional for up to one year. They are powerful and safe tools for long-term LDLc management, and thus may represent a novel therapeutic approach for the prevention and/or treatment of LDL hypercholesterolemia-related cardiovascular diseases in humans.
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